Despite mixed evidence, 75% of Americans take nutritional supplements, underlining the need for physician-patient dialogue. Yvette C. Terrie, RPh, and Danielle Green, RDN, discuss the obesity epidemic and the many benefits of a holistic approach. FDA approval of a novel non-opioid analgesic will hopefully address the needs of many patients with acute pain. Self-care for clinicians is the foundation of healthy practices. Antibiotic misuse, poor infection control, and high transmission rates of resistant pathogens fuel antimicrobial resistance. Healthcare professionals and patients share perspectives on US healthcare hurdles. Physicians and pharmacists improve patient care and outcomes through effective teamwork. Yvette C. Terrie, RPh, shares insights into addressing non-adherence and motivating patients to adhere to medication. Different strategies physicians can use to ensure more patients are informed about the benefits of vaccination. Empathy is a critical part of healthcare and is very much needed today. A lack of patient understanding about proper medication use can adversely affect clinical outcomes. Healthcare professionals can help combat medical misinformation. When clinicians become patients, they report greater empathy for their patients.