Halloween drives an influx of ophthalmic emergencies and infections caused by nonprescription contact lenses, masks and more. Adding a GON block to triple intravenous therapy significantly improved acute migraine pain relief in the ED. In chronic low back pain treatment, buprenorphine buccal film was tied to fewer treatment-emergent AEs versus CII opioids. Preterm neonates who underwent LSCI for ROP screening exhibited lower pain scores. Daily candesartan 16 mg significantly lowered migraine frequency for adults with episodic migraine.  Prompt opioid pain relief in the ED significantly reduced hospitalization rates for pediatric sickle cell disease. Repeat MVD offered the most durable longterm pain relief for recurrent or persistent TN after failed MVD. A novel, automated FEA methodology for lumbar spine biomechanics reduced model preparation time by 97.9%. Confounding factors, rather than prenatal opioid use only, account for most neurodevelopmental risk in exposed children. Dr. Kameelah Phillips discusses strategies for treating postpartum hemorrhage and research priorities to improve outcomes.  A weight loss intervention led to reduced CMP severity tied to improved diet quality, independent of changes in adiposity. Pairing TPVB with ESPB significantly reduces rebound pain after video-assisted thoracoscopic surgery. Ibuprofen and acetaminophen raised E. coli mutation rates and ciprofloxacin resistance. En-DCR improves chronic dacryocystitis symptoms and enhances vision-related quality of life, especially with earlier surgery. 'Artificial cartilage' could enable precise drug delivery for arthritis by releasing drugs in response to chemical changes. In knee osteoarthritis, minor adjustments to foot angle while walking can improve pain and may slow disease progression. A brief music intervention significantly reduced pain and anxiety among emergency department patients with acute back pain. Researchers found comorbidities were more prevalent in patients with axial spondyloarthritis than the general population. An ERAS pathway incorporating a preoperative ESP block significantly reduced opioid requirements and pain post-PCNL. Patients with chronic migraine and medication overuse headache face greater pain catastrophizing.