Halloween fun can turn risky—educate patients and prepare teams to prevent candy, costume, and safety hazards. HEPA purifiers in US elementary school classrooms reduced respiratory virus diversity but not overall viral burden. Sebastién Maury, MD, PhD, discusses the protective capacity of RSV vaccinations for adult patients who have undergone HSCT. Updated COVID-19 vaccine availability modestly increased 30-day uptake in the ED. CMV D+/R+ kidney transplant recipients showed significant cognitive decline 3 to 8 years after transplant. An article in Pneumonia highlighted RSV's burden and risk factors for progression to severe disease. Research supports use of pivmecillinam as an effective and well-tolerated treatment for uncomplicated acute cystitis. Higher lactate-to-hematocrit ratio (LHR) values were associated with significantly worse short- and long-term outcomes. Tailoring antibiotic administration timing to patient risk in sepsis care may improve outcomes and reduce overtreatment. Latent TB risk was higher in male patients, patients treated with golimumab or chloroquine, and current smokers. A single dose of clesrovimab protected healthy infants against mild, moderate, and severe RSV disease. Surgical antimicrobial prophylaxis noncompliance tripled the risk for surgical site infections and increased hospital stays. Patients with Fournier gangrene experienced much longer LOS and higher costs than patients treated for non-perineal NSTIs. FMT significantly reduced recurrent urinary tract infections for women who were postmenopausal. A recent review highlights sepsis-induced immunosuppression as a key driver of mortality. Malnutrition, genetic variants, chemotherapy, and even biological sex may affect the performance of the measles vaccine. With modern tools, antibiotic prophylaxis for upper gastrointestinal bleeding in those with cirrhosis may not be necessary. Stigma and lack of support hinder PrEP use among Black women; clinician bias and discrimination worsen disparities. Ibuprofen and acetaminophen raised E. coli mutation rates and ciprofloxacin resistance. Researchers said increasing vaccine uptake in these patients should be prioritized given their high risk for infection.