New evidence suggests metformin could enhance muscle strength and mass while reducing mortality in older patients with T2DM. Oscillometry offers a promising alternative to spirometry for diagnosing asthma and COPD in primary care. Women showed a stronger association between lower subjective social status and an imaging marker of cardiac fibrosis. Rates of diabetic retinal disease have increased in recent years, but its vision-threatening components have decreased. Language preference may impact rates of continuous glucose monitoring prescriptions among patients with type 2 diabetes. Richard Stefanacci, DO, MGH, MBA, discusses a study that found that patients with SLE had significantly greater frailty. Which of the following lifestyle factors is most often emphasized in functional medicine for chronic disease reversal? Collaborative care for OUD in primary care cut opioid use more than standard care, supporting integrated treatment models. ECG T wave inversion features can predict underlying cardiomyopathy in young, apparently healthy individuals. Dr. Francis O’Connor discusses effective methods and strategies clinicians can use to identify and manage heat stroke. Rising rates of IBD in older patients indicate a need for management that considers polypharmacy, comorbidities, and frailty. A pediatric endocrinologist outlines how clinicians can diagnose and treat growth hormone deficiency earlier in children. Dr. Chelsea Dorsey discusses CVI as a debilitating, underdiagnosed disease with high costs and limited treatments. Improving PrEP use in heterosexual minority men requires strategies that integrate HIV risk education and health literacy. Even subclinical depression influenced rates of patient retention in a digital weight loss program. Dermatologist Jennifer Cather, MD, shares best practices for conducting genital examinations for patients with psoriasis. Dr. Stephanie Nahas shares expert migraine prevention insights and strategies. Youth suicidal ideation followed distinct paths, linked to early-life mental health symptoms and adolescent distress. An obesity program implemented in a primary care setting yielded clinically significant initial and maintained weight loss. Sarcopenia and sarcopenic obesity were associated with an increased risk of 1-year mortality in patients with hip fractures.